central activity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2710	TCS 1102		OX Receptor
	TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).		OX Receptor
T77676	(Z)-Metanicotine 2HCl	(Z)-Metanicotine 2HCl(1129-68-6 Free base)	Others
	(Z)-Metanicotine 2HCl has analgesic activity and is used in the treatment of central system disorders.		Others
T6S0627	Mesaconitine		TNF
	1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system.		TNF
T0702	Gabapentin	Neurontin,Gabapentine,Aclonium	Calcium Channel , GABA Receptor
	Gabapentin (Neurontin) is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity.		Calcium Channel , GABA Receptor
T1946	Felbamate	W-554,ADD-03055	NMDAR , iGluR
	Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.		NMDAR , iGluR
T77731	ERK5-IN-6		ERK
	ERK5-IN-6 is a potent inhibitor of ERK5 kinase.ERK5-IN-6 exhibits antiproliferative activity, anticonvulsant activity, and antitumor activity, and can be used in the study of central nervous system-related disorders.		ERK
T6445	Cilomilast	SB-207499,Ariflo	PDE
	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.		PDE
T68127	Picenadol	LY-150720,LY150720,LY 150720	Others
	Picenadol (LY 150720) is a racemic mixture of N-methyl-4-phenylpiperidine derivatives with agonist-antagonist opioid properties.Picenadol has central analgesic activity.		Others
T2407	Tiagabine	TGB,NO050328,Gabitril,NO328	GABA Receptor
	Tiagabine (NO050328) is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity.		GABA Receptor
T0440	Oxcarbazepine	GP 47680	Apoptosis , Sodium Channel
	Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.		Apoptosis , Sodium Channel
T6649	(S)-(+)-Rolipram	(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram	Apoptosis , PDE
	(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.		Apoptosis , PDE
T0680	Lamotrigine	LTG,BW430C	5-HT Receptor , Sodium Channel , Autophagy
	Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.		5-HT Receptor , Sodium Channel , Autophagy
T60707	Quinupramine
	Quinupramine is an orally active antidepressant that shows antidepressant activity associated with the central serotonin system, but not with the β-adrenergic system. Quinupramine is able to penetrate into the CNS and af...
T16115	MLi-2		LRRK2
	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce...		LRRK2
T2156	WP1066		Apoptosis , JAK , STAT
	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Bra...		Apoptosis , JAK , STAT
T0806	Flunarizine dihydrochloride	Flunarizine 2HCl,KW-3149,R14950	Calcium Channel , Dopamine Receptor , Sodium Channel
	Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of mig...		Calcium Channel , Dopamine Receptor , Sodium Channel
T26778	Besipirdine	HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493	Sodium Channel , Adrenergic Receptor
	Besipirdine (HP 749 free base) is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine inhibits voltage-dependent sodium-potassium channels and inhibits biogeni...		Sodium Channel , Adrenergic Receptor
T1790	Fosaprepitant dimeglumine	L785298,MK-0517,Fosaprepitant dimeglumine salt	Neurokinin receptor
	Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion...		Neurokinin receptor
TN2322	Yangambin		Calcium Channel , PAFR
	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti...		Calcium Channel , PAFR
T10893	CS-722 Free base		Others
	CS-722 Free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 Free base may inhibit spontaneous inhibitory post-synaptic current and excitatory post-...		Others